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Friday, Jan 09, 2009 | 02:20 PM
Madisons Foundation - Moms And Dads In Search Of Needed Support
Wells Syndrome
Eosinophilic Cellulitis
Sunday, 15 August 2004
Last Updated Sunday, 15 August 2004
What
Wells Syndrome is a rare disorder of the immune system that is characterized by the presence of an itchy rash that can appear as flat red patches or bumpy lesions on the skin. These patches or lesions form in a period of 2-3 days and usually disappear within weeks.Who
Wells Syndrome affects males and females equally and there is no known racial predilection. It is very rare with only 80 cases reported in both adults and children since it was discovered in 1979.Signs and Symptoms
Children with Wells Syndrome may have lesions on the skin (face, legs, or arms) that have several of the following characteristics: • Swollen • Reddish • Purplish borders • Hardened and bumpy • Blister-like • Not warm to the touch These lesions develop over 2-3 days and slowly disappear over 2-8 weeks. They may be bright red when they first erupt, but then slowly fade to a bluish color over several weeks. Scarring generally does not occur and in rare cases there is associated fever, muscle aches, and breathing difficulties.Possible Causes
The exact cause of Wells Syndrome is unknown. In a few cases, it seems that certain medications, like aspirin, penicillin, or local pain killers, are responsible for the skin lesions. It is also hypothesized that eosinophilic cellulitis is a symptom of other medical conditions. Bug bites, viral and fungal infections, and parasitic infestation can also be factors in developing this syndrome. In a few cases, the syndrome runs in the family. Some believe that Wells syndrome is a type of allergic reaction. Eosinophils are a type of white blood cell that stimulate allergic responses.Diagnosis
Making the diagnosis of Wells Syndrome is based on recognition of the skin lesions and clinical symptoms. A skin biopsy can be performed by a dermatologist and will show an abundance of eosinophils. Furthermore, blood tests such as a complete blood count can be performed which will also demonstrate an elevated eosinophil count.Treatment
The treatment of Wells syndrome is focused on controlling the inflammation and discomfort associated with the skin rash. This is accomplished with the application of topical medicines such as topical corticosteroids, antihistamines (Benadryl™). Oral prednisone, a corticosteroid that helps relieve inflammation, has also been effective in treating Wells Syndrome. Other medications include griseofulvin (an antifungal medication), cyclosporine (medication that suppresses the immune system), and dapsone (an antibiotic). In many cases, the patches will disappear without any intervention.Prognosis
The prognosis is excellent. The lesions disappear after a few weeks and often do not form scars. Occasionally, these lesions may recur.Connect with other parents
In the spirit of community and support, Madisons Foundation offers the unique service of connecting parents of children with rare diseases. If you would like to be connected to other parents of children with this disease, please fill out this brief form.Weblinks
National Institute of Allergy and Infectious Diseases:
Provides general information and information about current research projects on allergies and infectious diseases.
American Academy of Dermatology:
This is a special kids’ section of the website. It provides general information about skin healthcare for the younger audience.
PeaceHealth
This site contains links to other allergy related national organizations.
American Autoimmune Related Diseases Association, Inc.
National organization geared toward educating the public on autoimmune diseases.